Publications by authors named "Alexandre V Existe"
Background: Malaria continues to cause burden in various parts of the world. Haiti, a Caribbean country, is among those aiming to eliminate malaria within a few years. Two surveys were conducted in Haiti during which we aimed to evaluate the performance of the simple and rapid procedure for ultra-rapid extraction-loop-mediated isothermal amplification (PURE-LAMP) method with dried blood spots as an alternative diagnostic method for malaria in the context of low to very low rates of transmission.
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- There is limited information on G6PD variants in Haiti, highlighting a need for relevant public health guidelines.
- The study found significant prevalence rates for specific G6PD mutations: 35.8% for A376G and 12.2% for G202A, along with a new mutation C370T in one participant.
- The A202 variant, which includes A376G and G202A mutations, shows a 16.6% prevalence and may affect the safety of certain medications like primaquine in individuals with G6PD deficiency.
We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance-associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. We recommend maintaining chloroquine as the first-line drug for malaria in Haiti. Artemisinin-based therapy can be used as alternative therapy.
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