Immunostaining of βA-Activin and Follistatin Is Decreased in HPV(+) Cervical Pre-Neoplastic and Neoplastic Lesions.

The activin-follistatin system regulates several cellular processes, including differentiation and tumorigenesis. We hypothesized that the immunostaining of βA-activin and follistatin varies in neoplastic cervical lesions. Cervical paraffin-embedded tissues from 162 patients sorted in control ( = 15), cervical intraepithelial neoplasia (CIN) grade 1 ( = 38), CIN2 ( = 37), CIN3 ( = 39), and squamous cell carcinoma (SCC; = 33) groups were examined for βA-activin and follistatin immunostaining.

Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women.

Background: Cervical cancer has high prevalence and mortality rates in worldwide female population. Persistent infection by high-risk Human Papillomavirus (hr-HPV) is the main cause of this cancer. However, many environmental, genetical, and epigenetical cofactors can modulate viral infection and cervical carcinogenesis.

Minichromosome maintenance 7 protein is a reliable biological marker for human cervical progressive disease.

Objective: This study focused on comparing the expression levels of p16, Ki-67, and minichromosome maintenance 7 (MCM7) protein in normal and affected cervical epithelium to ascertain the biological significance of these markers in detecting progressive cervical disease.

Methods: A quantitative and based on-scanning-microscopy analysis of the three markers expression was performed in normal and cervical intraepithelial neoplasia (CIN) I, II, and III tissues. p16 area as well as p16, Ki-67, and MCM7 positive cells or nuclei were evaluated according to their distribution and extent through the cervical epithelium.

Ectopic Cutaneous Schistosomiasis mansoni in the Sacral Region.

The authors report one case of late cutaneous Schistosomiasis mansoni in a biopsy of a skin lesion in the sacral region in a 51-year-old female living in Contagem, Minas Gerais. The patient was treated successfully with oxamniquine (Mansil®).

Cervical intraepithelial neoplasia recurrence after conization in HIV-positive and HIV-negative women.

Objectives: To evaluate the recurrence rates of cervical intraepithelial neoplasia (CIN) in a cohort of HIV-infected and noninfected women who underwent the loop electrosurgical excision procedure (LEEP).

Methods: A prospective cohort study of 94 HIV-positive and 107 HIV-negative women, both with CIN, treated with LEEP. The diagnosis of recurrence was established after biopsy.

[The tumoral form of cerebellar schistosomiasis: case report and measure of granulomas].

An unusual case of the tumoral form of cerebellar Schistosomiasis mansoni, in a 15 year-old male diagnosed by biopsy, with neurological signs and symptoms 60 days prior to surgery. Computerized tomography show a hyperdense expanding lesion located in cerebellum, suggesting glioma. Histopathological examination showed numerous S.

[Primary low grade B-cell lymphoma MALT type of the duramater: case report].

We describe a rare case of nodular and low grade non-Hodgkin malignant lymphoma, MALT type, with morphological and immunohistochemical features of lymphoplasmocytic (REAL classification), of immunophenotype of B lymphocytes and detected monoclonal of immunoglobulin kappa light chains, with low proliferation grade (<10%). The tumor was primitive of the left parietal duramater in a 36 years old woman, who presented neurological clinical symptoms four months before the surgery. After surgery, she was submitted to chemotherapy and radiotherapy with good results.