The Identification of Nuclear FMRP Isoform Iso6 Partners.

A deficiency of FMRP, a canonical RNA-binding protein, causes the development of Fragile X Syndrome (FXS), which is characterised by multiple phenotypes, including neurodevelopmental disorders, intellectual disability, and autism. Due to the alternative splicing of the encoding gene, multiple FMRP isoforms are produced consisting of full-length predominantly cytoplasmic (i.e.

Complex apodized Bragg grating filters without circulators in silicon-on-insulator.

Bragg gratings operating in reflection are versatile filters that are an important building block of photonic circuits but, so far, their use has been limited due to the absence of CMOS compatible integrated circulators. In this paper, we propose to introduce two identical Bragg gratings in the arms of a Mach-Zehnder interferometer built with multimode interference 2 x 2 couplers to provide a reflective filter without circulator. We show that this structure has unique properties that significantly reduce phase noise distortions, avoid the need for thermal phase tuning, and make it compatible with complex apodization functions implemented through superposition apodization.

Bandpass integrated Bragg gratings in silicon-on-insulator with well-controlled amplitude and phase responses.

Bandpass filters with square shape amplitude responses and well-controlled dispersion characteristics are achieved by accurate apodization of Bragg grating structures in silicon-on-insulator waveguides. For these devices, precise tailoring of their frequency response typically requires low coupling coefficients and relatively long on-chip propagation lengths. These challenges are addressed by implementing apodization by phase-modulation and using wider strip waveguides to reduce phase noise.

Multiwavelength super-structured Bragg grating laser for tunable repetition rate mode-locked operation.

A multiwavelength laser based on a super-structured Bragg grating is designed and fabricated on multiquantum well AlGaInAs-InP. This laser exhibits phase locking via mutual injection of the neighboring cavities assisted by four wave mixing. We present optical and electrical characterization of its emission regimes showing a complex dynamic behavior.

Characterization and reduction of spectral distortions in silicon-on-insulator integrated Bragg gratings.

A major issue in the fabrication of integrated Bragg grating filters in highly confined waveguides is the average effective index fluctuations caused by waveguide dimension variations. Lateral variations are caused by the sidewall roughness created during the etching process while vertical variations are coming from the wafer silicon layer thickness non-uniformity. Grating spectral distortions are known to result solely from the low spatial frequency components of these variations.

Integrated Bragg gratings in spiral waveguides.

Over the last two decades, many filters requiring custom spectral responses were obtained from photo-inscribed fiber Bragg gratings because of the flexibility inherent to this technology. However, Bragg gratings in silicon waveguides have the potential to provide faster and more efficient tuning capabilities when compared to optical fiber devices. One drawback is that Bragg gratings filters with elaborate spectral amplitude and phase responses often require a long interaction length, which is not compatible with current integration trends in CMOS compatible photonic circuits.