Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the C677T Polymorphism: A Randomized Trial.

Methylenetetrahydrofolate reductase () C677T polymorphism associated with body fat accumulation could possibly trigger an inflammatory process by elevating homocysteine levels and increasing cytokine production, causing several diseases. This study aimed to evaluate the effects of food intervention, and not folate supplements, on the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in overweight and obese women with the C677T polymorphism. A randomized, double-blind eight-week clinical trial of 48 overweight and obese women was conducted.

Influence of the C677T Polymorphism of the Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention.

The C677T polymorphism of the methylenetetrahydrofolate reductase gene () is related to folate metabolism and can alter the levels of biochemical markers.: Investigate the influence of the C677T polymorphism on the effects of a dietary folate intervention on oxidative stress in women with overweight or obesity.: Forty-eight adult women with overweight or obesity were subjected to a 24-hour dietary recall, anthropometric measurements, biochemical analysis, and genotyping of the C677T polymorphism.

Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the gene, lipid profile and oxidative stress in overweight or obese women.

Background: Studies of genes that play an important role in the development of obesity are needed, especially studies focusing on genes that regulate food intake and affect nutrient metabolism. For example, the beta-3 adrenergic receptor () responds to noradrenaline and mediates lipolysis in adipocytes.

Methods: This was a controlled intervention study involving 40 overweight and obese adult women in which food intake, anthropometric measurements, biochemical analyses, and methylation levels of the gene were evaluated before and after intervention.