Solitary rectal ulcer syndrome in 102 patients: Do different phenotypes make sense?

Background: Little is known about the pathophysiological mechanisms of solitary rectal ulcer syndrome (SRUS).

Aims: We aim to identify the different phenotypes, taking into account complaints, anatomy and anorectal physiology.

Methods: Complaints, endoscopy results, and physiology data of patients with histologically proven SRUS were collected and analysed.

Incidental anal fluorodeoxyglucose uptake: Should we further examine the patient?

Background: There are no studies on incidental anal F-fluorodeoxyglucose (FDG) uptake.

Aim: To assess the rate and aetiologies of incidental anal FDG uptake and to evaluate the correlation between FDG positron-emission tomography/computed tomography (PET/CT) parameters and the diagnosis of an anorectal disease.

Methods: The data from patients with incidental anal FDG uptake were retrospectively analysed.

Quality of life in 1870 patients with constipation and/or fecal incontinence: Constipation should not be underestimated.

Background: Quality of life is increasingly seen as important, but remains difficult to assess in patients with functional anorectal complaints.

Objective: We aimed to quantify quality of life and to analyse the symptomatic descriptors associated with a poor outcome in patients with faecal incontinence (FI) and/or constipation.

Methods: The characteristics of the patients, data from self-administered questionnaires and from physical examinations were evaluated prospectively for all cases of functional anorectal disease over a period of thirteen years.

Anal Fistulas in Severe Perineal Crohn's Disease: Mri Assessment in the Determination of Long-Term Healing Rates.

Background & Aims: The European Crohn's and Colitis Organization recommends magnetic resonance imaging (MRI) of anal fistulas to decide on the drug/surgery strategy. No evidence is available on the long-term impact of MRI features on fistula healing. The aim of this study was to evaluate the benefit of combined drug/surgery strategies for the treatment of perianal Crohn's fistulas based on MRI factors at referral.

Anal ulcerations in Crohn's disease: Natural history in the era of biological therapy.

Background: The natural history of anal ulcerations in Crohn's disease remains unknown.

Aims: To assess the long-term outcomes of anorectal ulcerations.

Methods: Data from consecutive patients with perineal Crohn's disease were prospectively recorded.