Publications by authors named "Alexandre Lalli"
The incidence of urinary tract infections caused by extended-spectrum β-lactamase (ESBL)-producing pathogens is increasing. These infections are associated with a long hospital stay in patients undergoing urological procedures. We aimed to demonstrate that significant intraprostatic diffusion of ertapenem is achieved after a single preoperative administration.
View Article and Find Full Text PDFQuantitation of isocitrate dehydrogenase (IDH)-induced D and L enantiomers of 2-hydroxyglutaric acid in biological fluids by a fully validated liquid tandem mass spectrometry method, suitable for clinical applications.
J Chromatogr B Analyt Technol Biomed Life Sci
June 2016
Article Synopsis
- A recent update in cancer research has identified metabolism and cellular energetics deregulation as important factors in cancer progression, particularly related to mutations in IDH enzymes that lead to 2-hydroxyglutaric acid (2-HGA) accumulation.
- Researchers developed a highly accurate and precise liquid chromatography tandem mass spectrometry method to quantify 2-HGA enantiomers in blood samples from acute myeloid leukaemia (AML) patients, which is useful for diagnosing IDH mutations.
- The method demonstrated strong validation results, with linear standard curves and low matrix effects, making it suitable for both clinical and preclinical applications.