Publications by authors named "Alexandre Gautier"
Article Synopsis
- The study investigates the effectiveness and safety of using a 3D computational model fused with real-time fluoroscopy to guide left atrial appendage closure (LAAC) for patients with non-valvular atrial fibrillation.
- The research included 106 patients who underwent the procedure, achieving a 100% success rate for device implantation and meeting primary efficacy criteria in 89% of cases.
- The approach was deemed safe, with only 1.9% of patients experiencing major complications, suggesting that this technique could enhance LAAC outcomes.
An 86-year-old woman was managed for a non-ST-segment elevation myocardial infarction. Coronary angiography revealed significant stenoses at the left anterior descending, left ostial circumflex (LCX), obtuse first marginal, and a Medina 1.0.
View Article and Find Full Text PDFBackground: Despite major advances in prevention and treatment, cardiovascular diseases - particularly acute myocardial infarction - remain a leading cause of death worldwide and in France. Collecting contemporary data about the characteristics, management and outcomes of patients with acute myocardial infarction in France is important.
Aims: The main objectives are to describe baseline characteristics, contemporary management, in-hospital and long-term outcomes of patients with acute myocardial infarction hospitalized in tertiary care centres in France; secondary objectives are to investigate determinants of prognosis (including periodontal disease and sleep-disordered breathing), to identify gaps between evidence-based recommendations and management and to assess medical care costs for the index hospitalization and during the follow-up period.
Article Synopsis
- * Despite its prevalence, vasospastic angina is often underdiagnosed, and specific tests to identify it are not frequently conducted due to inconsistent protocols.
- * The French Coronary Atheroma and Interventional Cardiology Group (GACI) released a position paper focusing on the criteria and protocols for conducting provocative tests to better diagnose and understand vasospastic angina.
Background And Aims: Data on new-onset atrial fibrillation (NOAF) in patients with chronic coronary syndromes (CCS) are scarce. This study aims to describe the incidence, predictors, and impact on cardiovascular (CV) outcomes of NOAF in CCS patients.
Methods: Data from the international (45 countries) CLARIFY registry (prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease) were used.
Article Synopsis
- The study investigates the best timing for performing percutaneous coronary interventions (PCI) in patients undergoing transcatheter aortic valve implantation (TAVI), a procedure for severe aortic stenosis with existing coronary artery disease (CAD).
- An analysis of 1,603 patients from the REVASC-TAVI registry shows that performing PCI after TAVI leads to better 2-year clinical outcomes, with significantly lower rates of all-cause death and major complications compared to PCI before or concurrently with TAVI.
- The findings suggest that scheduling PCI after TAVI may be more beneficial, but further confirmation through randomized clinical trials is needed.
Background: Large-scale registries can provide valuable complementary data to randomized controlled trials (RCT) for the postmarketing evaluation of coronary stents, but their scientific relevance remains debated.
Methods: We sought to compare the evidence on the performance of a single coronary stent platform generated by the RCT for its regulatory approval and a well-conducted international registry. Patients treated with the Ultimaster coronary stent in the CENTURY II (CII-UM) trial (n = 551) were compared to patients in the real-world e-ULTIMASTER (e-UM) registry (n = 35,389).
Article Synopsis
- The study assesses the management of stable coronary artery disease (CAD) in patients undergoing transcatheter aortic valve implantation (TAVI), highlighting inconsistencies in existing evidence.
- Using data from the REVASC-TAVI registry with 2407 patients, researchers compared outcomes between those who underwent complete versus incomplete myocardial revascularization.
- Findings indicate no significant differences in all-cause death or composite outcomes (like stroke and rehospitalization for heart failure) between the two groups after 2 years, suggesting that the completeness of revascularization may not impact outcomes for TAVI patients with stable CAD.
Background: The evolution of patients hospitalized with coronavirus disease 2019 (COVID-19) is still hard to predict, even after several months of dealing with the pandemic.
Aims: To develop and validate a score to predict outcomes in patients hospitalized with COVID-19.
Methods: All consecutive adults hospitalized for COVID-19 from February to April 2020 were included in a nationwide observational study.
Introduction: Long drug-eluting stents may limit the issue of overlapping multiple stents when treating long coronary lesions.
Aim: The aim of the study was to assess the safety and efficacy of the 48 mm Xience Xpedition everolimus-eluting stent (48mm-EES) for the treatment of long coronary lesions, in an all-comer population.
Methods: Patients receiving at least one 48mm-EES were prospectively included from March 2014 to December 2018.
Article Synopsis
- The Critical COVID France (CCF) study examined the effects of COVID-19 on 2868 hospitalized patients, focusing on those aged 18-45, who made up 11.2% of the sample.
- Young patients (18-45 years old) had lower rates of severe outcomes like ICU transfers and in-hospital deaths compared to older patients, but they experienced higher rates of certain cardiovascular issues like pericarditis and myocarditis.
- Despite lower overall severity, COVID-19 still posed significant cardiovascular risks for young patients, highlighting the importance of understanding its impacts on this age group.
Background: Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population.
Aims: To assess the burden and impact of cardiovascular comorbidities in women with COVID-19.
Methods: All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included.
Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a public health crisis. Only limited data are available on the characteristics and outcomes of patients hospitalized for COVID-19 in France.
Aims: To investigate the characteristics, cardiovascular complications and outcomes of patients hospitalized for COVID-19 in France.
Prognostic value of right ventricular dilatation in patients with COVID-19: a multicentre study.
Eur Heart J Cardiovasc Imaging
March 2022
Aims: Although cardiac involvement has prognostic significance in coronavirus disease 2019 (COVID-19) and is associated with severe forms, few studies have explored the prognostic role of transthoracic echocardiography (TTE). We investigated the link between TTE parameters and prognosis in COVID-19.
Methods And Results: Consecutive patients with COVID-19 admitted to 24 French hospitals were retrospectively included.
Background: Our study aimed to compare the clinical outcomes of patients with and without diabetes admitted to hospital with COVID-19.
Methods: This retrospective multicentre cohort study comprised 24 tertiary medical centres in France, and included 2851 patients (675 with diabetes) hospitalized for COVID-19 between 26 February and 20 April 2020. A propensity score-matching (PSM) method (1:1 matching including patients' characteristics, medical history, vital statistics and laboratory results) was used to compare patients with and without diabetes (n = 603 per group).
The aim of this study was to describe the effects of chronic systemic corticosteroid treatment (SCT) on early and late outcomes after transcatheter aortic valve implantation (TAVI). From October 2006 to November 2018, 1,299 patients underwent TAVI in our institution. Among them, 48 (3.
View Article and Find Full Text PDFAims: Inflammatory mediators, including blood cells and their products, contribute critically to atherogenesis, but the igniting triggers of inflammation remain elusive. Atherosclerosis develops at sites of flow perturbation, where the enhanced haemodynamic stress could initiate the atherogenic inflammatory process due to the occurrence of mechanic injury. We investigated the role of haemodynamic stress-induced breaches, allowing the entry of blood cells in the arterial intima, in triggering inflammation-driven atherogenesis.
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