Publications by authors named "Alexandre Fagart"
A 50-year-old woman presented a dry syndrome, joint pain, inflammatory syndrome, polyclonal hypergammaglobulinemia, and tubulointerstitial nephritis. Imaging studies (including FDG PET/CT) revealed infrarenal retroperitoneal fibrosis with periaortitis and hypermetabolic osteosclerotic lesions. Bone scintigraphy demonstrated intense uptake in the femoral, tibial, and radial regions, suggestive of non-Langerhans histiocytosis, specifically Erdheim-Chester disease.
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- VEXAS syndrome is an adult-onset autoinflammatory disease caused by mutations in the UBA1 gene, first identified in 2020.
- Patients typically present symptoms of inflammatory syndromes like relapsing polychondritis or hematologic conditions like myelodysplastic syndrome.
- A case report describes a 70-year-old man with VEXAS syndrome showing a unique "leopard man" appearance on FDG PET/CT imaging, indicating abnormal bone marrow activity.
Article Synopsis
- Immune checkpoint inhibitors (ICI) are effective in treating certain cancers but can lead to hormonal side effects, especially affecting the thyroid, resulting in conditions like hyperthyroidism and hypothyroidism.
- A case study of a 72-year-old man illustrates how ICI therapy for metastatic melanoma led to an initial worsening of hyperthyroidism due to a toxic nodule, followed by persistent hypothyroidism requiring long-term treatment, with ultrasound revealing significant thyroid changes.
- The case suggests that while the evolution of thyroid conditions under ICI therapy is not well-documented, pre-existing toxic nodules are not a reason to avoid ICI treatment, as long as patients are monitored closely.
Photodynamic therapy (PDT) appears to be a promising strategy in biomedical applications. However, the complexity of its parameters prevents wide acceptance. This work presents and characterizes a novel optical device based on knitted light-emitting fabrics and dedicated to in vitro PDT involving low irradiance over a long illumination period.
View Article and Find Full Text PDFObjective: 18F-fluorodeoxyglucose PET/CT (FDG-PET/CT) is widely used in patients with large vessel vasculitis. The benefits of FDG-PET/CT in PAN has only ever been assessed in three case reports. Our aim was to describe FDG-PET/CT findings in 10 patients with newly diagnosed PAN.
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