Publications by authors named "Alexandre F Coimbra"
Article Synopsis
- The study aimed to evaluate how quantitative metrics from high-resolution computed tomography (HRCT) could predict the rate of decline in forced vital capacity (FVC) in systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF) patients.
- It analyzed data from 271 patients who were part of various clinical trials, using the Imbio lung texture analysis tool to assess HRCT scans.
- The results indicated weak or inconsistent correlations between the HRCT metrics and FVC decline, suggesting limited prognostic value in these patient populations.
Purpose: Positron emission tomography (PET)/ computed tomography (CT) has been extensively used to quantify metabolically active tumors in various oncology indications. However, FDG-PET/CT often encounters false positives in tumor detection due to fluorodeoxyglucose (FDG) accumulation from the heart and bladder that often exhibit similar FDG uptake as tumors. Thus, it is necessary to eliminate this source of physiological noise.
View Article and Find Full Text PDFPurpose: GDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.
Patients And Methods: GDC-0084 was administered orally, once daily, to evaluate safety, pharmacokinetics (PK), and activity.