Publications by authors named "Alexandre F C Galvao"
Duguetia pycnastera Sandwith (Annonaceae) is a tropical tree that can be found in the Guyanas, Bolivia, Venezuela, and Brazil. In Brazil, it is popularly known as “ata”, “envira”, “envira-preta”, and “envira-surucucu”. In the present work, we investigated the in vitro and in vivo HepG2 cell growth inhibition capacity of D.
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- R. E. Fries, a tree native to the Brazilian Amazon, has its essential oil (EO) evaluated for its cytotoxic and antitumor effects against liver cancer using HepG2 cells as a model.
- The EO, characterized through hydrodistillation and analyzed by GC-MS and GC-FID, was found to contain key compounds such as germacrene D and caryophyllene oxide.
- The study demonstrated that the EO exhibited significant anti-liver cancer properties in vitro and in vivo, decreasing tumor mass by 32.8-57.9% and increasing apoptotic cells in HepG2 cells.
Background: Great biodiversity is a highlight of Brazilian flora. In contrast, the therapeutic potentialities of most species used in folk medicine remain unknown. Several of these species are commonly used to treat cancer.
View Article and Find Full Text PDFPhytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known alkaloids (13-21). The structures of the new alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.
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