Publications by authors named "Alexandre De Goes Martini"
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Synopsis of recent research by authors named "Alexandre De Goes Martini"
- Alexandre de Goes Martini's recent research centers on the identity and function of renin cells in the kidney, highlighting the role of the transcription factor Gata3 in maintaining renin cell identity and plasticity in response to physiological challenges.
- In comparative studies involving renin-null zebrafish and mice, Martini's team utilized CRISPR-Cas9 technology to explore the renin-angiotensin system in a low blood pressure environment, employing single-cell RNA sequencing to analyze differences in transcriptome profiles.
- Martini's work also investigates the transformative capability of smooth muscle cells along renal arterioles into renin cells during hypotensive conditions, emphasizing the critical involvement of prorenin receptors in normal kidney development and overall homeostasis.
