Publications by authors named "Alexandre DE Matos Soeiro"
Purpose: To assess the effect of antisense therapy to block kallikrein-kinin pathway in COVID-19 patients.
Material And Methods: Randomized, placebo-controlled, double blind, controlled trial enrolling hospitalized COVID-19 patients that required supplementary oxygen to sustain peripheral oxygen saturation. Key exclusion criteria included use of mechanical ventilation or vasopressors, and patients with more than 10 days since symptom onset or more than 48 h of oxygen use.
Background: In patients complaining common symptoms such as chest/abdominal/back pain or syncope, acute aortic syndromes (AAS) are rare underlying causes. AAS diagnosis requires urgent advanced aortic imaging (AAI), mostly computed tomography angiography. However, patient selection for AAI poses conflicting risks of misdiagnosis and overtesting.
View Article and Find Full Text PDFPredictors of bleeding and thrombotic events among patients admitted to the hospital with COVID-19 and elevated D-dimer: insights from the ACTION randomized clinical trial.
J Thromb Thrombolysis
August 2024
Article Synopsis
- Therapeutic anticoagulation in COVID-19 patients shows mixed outcomes, complicating the selection of suitable patients due to balancing thrombotic and bleeding risks.
- A post-hoc analysis of the ACTION trial examined factors linked to bleeding and thrombotic events, using logistic regression to identify significant variables.
- Key findings included that non-invasive respiratory support related to thrombotic risks, invasive ventilation increased risks for both outcomes, and factors like creatinine levels and a history of coronary disease were important in determining thrombotic risk.
Potential performance of a 0 h/1 h algorithm and a single cut-off measure of high-sensitivity troponin T in a diverse population: main results of the IN-HOPE study.
Eur Heart J Acute Cardiovasc Care
November 2023
Article Synopsis
- * Conducted across 16 sites in Brazil, the study included both a prospective cohort (583 patients) and a retrospective analysis (4,914 patients) to evaluate the effectiveness of troponin levels in diagnosing AMI risk.
- * Results indicated that 74.4% of the prospective cohort qualified for a rule-out approach based on troponin levels, highlighting the potential for this method to improve patient evaluation in emergency settings.
Quality improvement program in Latin America decreases mortality after cardiac surgery: a before-after intervention study.
Int J Surg
October 2022
Background: The current challenge of cardiac surgery (CS) is to improve outcomes in adverse scenarios. The aim of this study was to assess the impact of a quality improvement program (QIP) on hospital mortality in the largest CS center in Latin America.
Methods: Patients were divided into two groups: before (Jan 2013-Dec 2015, n = 3534) and after establishment of the QIP (Jan 2017-Dec 2019, n = 3544).
Background: It has recently been demonstrated that the application of high-energy ultrasound and microbubbles, in a technique known as sonothrombolysis, dissolves intravascular thrombi and increases the angiographic recanalization rate in patients with ST-segment-elevation myocardial infarction (STEMI).
Objective: To evaluate the effects of sonothrombolysis on left ventricular wall motion and myocardial perfusion in patients with STEMI, using real-time myocardial perfusion echocardiography (RTMPE).
Methods: One hundred patients with STEMI were randomized into the following 2 groups: therapy (50 patients treated with sonothrombolysis and primary coronary angioplasty) and control (50 patients treated with primary coronary angioplasty).
Update of the Brazilian Society of Cardiology's Perioperative Cardiovascular Assessment Guideline: Focus on Managing Patients with Percutaneous Coronary Intervention - 2022.
Arq Bras Cardiol
February 2022
Diagnostic Performance of Coronary Tomography Angiography and Serial Measurements of Sensitive Cardiac Troponin in Patients With Chest Pain and Intermediate Risk for Cardiovascular Events.
Arq Bras Cardiol
May 2022
Background: Coronary tomography angiography (CTA) has been mainly used for chest pain evaluation in low-risk patients, and few data exist regarding patients at intermediate risk.
Objective: To evaluate the performance of serial measures of sensitive troponin and CTA in intermediate-risk patients.
Methods: A total of 100 patients with chest pain, TIMI risk scores of 3 or 4, and negative troponin were prospectively included.
Tocilizumab in SARS-COVID19 following postoperative laparoscopic transhiatal esophagectomy for the adenocarcinoma of esophagogastric tumor: A case report.
Int J Surg Case Rep
September 2021
Introduction And Importance: Esophagectomy for esophageal cancer is one of the most challenging surgical procedures, with high rates of morbidity, especially from respiratory complications. SARS-COVID19 represents a health threat nowadays. Peri-operative SARS-COVID19 infection after esophagectomy might negatively affect the postoperative outcomes.
View Article and Find Full Text PDFBrazilian Society of Cardiology Guidelines on Unstable Angina and Acute Myocardial Infarction without ST-Segment Elevation - 2021.
Arq Bras Cardiol
July 2021
Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial.
Lancet
June 2021
Background: COVID-19 is associated with a prothrombotic state leading to adverse clinical outcomes. Whether therapeutic anticoagulation improves outcomes in patients hospitalised with COVID-19 is unknown. We aimed to compare the efficacy and safety of therapeutic versus prophylactic anticoagulation in this population.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to develop a simplified scoring tool (AORTAs) for assessing acute aortic syndromes (AASs), which is based on 6 key clinical signs, making it easier for healthcare providers to evaluate patients.
- The AORTAs score demonstrated better performance than the traditional aortic dissection detection score, reclassifying a considerable proportion of patients for more accurate diagnosis.
- The integration of the AORTAs score with an age-adjusted d-dimer (DD) test showed high sensitivity for ruling out AASs, though with a slight decrease in specificity, making it a valuable tool in clinical practice.
Position Statement on the Use of Antiplatelet Agents and Anticoagulants in Patients Infected with the New Coronavirus (COVID-19) - 2020.
Arq Bras Cardiol
August 2020
Background: Evidence regarding biomarkers for risk prediction in patients with infective endocarditis (IE) is limited. We aimed to investigate the value of a panel of biomarkers for the prediction of in-hospital mortality in patients with IE.
Methods: Between 2016 and 2018, consecutive IE patients admitted to the emergency department were prospectively included.