Publications by authors named "Alexandre Connolly"
The signaling mechanisms of the angiotensin II type 2 receptor (ATR), a heptahelical receptor, have not yet been clearly and completely defined. In the present contribution, we set out to identify the molecular determinants involved in ATR activation. Although ATR has not been shown to engage G, G, G, and β-arrestin (βarr) pathways as does the ATR upon angiotensin II (AngII) stimulation, the atypical positioning of helix VIII in the recently published ATR structure may play a role in the receptor's capacity to couple to downstream effectors.
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- Polycystic ovary syndrome (PCOS) is linked to hormonal imbalances, infertility, and metabolic issues, with nonesterified fatty acids (NEFAs) possibly causing cellular dysfunction and worsening symptoms.
- Lipotoxicity from excess NEFAs can lead to increased androgen production and insulin resistance, which in turn exacerbates hyperandrogenemia in women with PCOS.
- Targeting lipotoxicity through insulin sensitization and the activation of angiotensin II type 2 receptors (AT2R) shows promise in improving symptoms and metabolic health in PCOS models.