Pinaverium bromide.

The structure of pinaverium bromide (systematic name: 4-[(2-bromo-4,5-di-meth-oxy-phen-yl)meth-yl]-4-{2-[2-(6,6-dimethyl-2-bi-cyclo-[3.1.1]hepta-nyl)eth-oxy]eth-yl}morpholin-4-ium bromide; CHBrNO), was determined at 110 K.

Crystal structures of two polymorphs of tixocortol pivalate.

Two polymorphs, () and (), of ()-{2-[(8,9,10,11,13,14,17)-11,17-dihy-droxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-deca-hydro-1-cyclo-penta-[]phenanthren-17-yl]-2-oxoeth-yl} 2,2-di-methyl-propane-thio-ate, CHOS, have been identified. They are ortho-rhom-bic, non-centrosymmetric (222). The structures display layers of mol-ecules conected O-H⋯O hydrogen bonds along the axis direction in polymorph () and along the axis direction in polymorph ().

Crystal structure of (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman.

The title compound, C11H11FO2, is a building block in the synthesis of the active pharmaceutical ingredient dl-nebivolol. The synthesis starting from the enanti-omerically pure (R)-6-fluoro-4-oxo-3,4-di-hydro-2H-chromene-2-carb-oxy-lic acid resulted in a mixture of two stereoisomers, namely (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman and (R)-6-fluoro-2-[(R)-oxiran-2-yl]chroman. The mixture was separated by column chromatography but only one stereoisomer crystallized.

A triclinic polymorph of (-)-(S)-N-benzyl-2-[(R)-6-fluoro-chroman-2-yl]-2-hy-droxy-ethanaminium bromide.

The title salt, C18H21FNO2 (+)·Br(-), determined at 115 K, crystallizes in the triclinic space group P1. The previously reported polymorph occurs in the monoclinic space group P21 and has two independent mol-ecules in the asymmetric unit [Peeters et al. (1993 ▶).

(R)-(-)-Quinuclidin-3-ol.

The structure of the title compound [alternatively called (R)-(-)-1-aza-bicyclo-[2.2.2]octan-3-ol], C7H13NO, at 100 K has hexa-gonal (P61) symmetry.

(S,S,S,S)-Nebivolol hydro-chloride hemihydrate.

The asymmetric unit of the title hydrated salt, C22H26F2NO4(+)·Cl(-)·0.5H2O, consists of an (S,S,S,S)-nebivolol {nebivol = bis-[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hy-droxy-eth-yl]ammonium} cation, a chloride anion and a half-occupancy water mol-ecule. The dihedral angle between the mean planes of the benzene rings is 50.