Publications by authors named "Alexandre Brochard"
Article Synopsis
- The hypothalamus has lots of different neurons that control behavior and metabolism, and these neurons can change over time.
- Researchers found special 'Ghost' neurons, which don't act like regular ones and were previously unnoticed by other methods.
- The number of Ghost neurons increases in mice that gain weight from unhealthy diets, but they can change back when the mice lose weight, showing that neurons can adapt based on diet.
Background And Aims: Through an exploratory proteomic approach based on typical hepatocellular adenomas (HCAs), we previously identified a diagnostic biomarker for a distinctive subtype of HCA with high risk of bleeding, already validated on a multicenter cohort. We hypothesized that the whole protein expression deregulation profile could deliver much more informative data for tumor characterization. Therefore, we pursued our analysis with the characterization of HCA proteomic profiles, evaluating their correspondence with the established genotype/phenotype classification and assessing whether they could provide added diagnosis and prognosis values.
View Article and Find Full Text PDFStrong breakthrough pain is one of the most disabling symptoms of cancer since it affects up to 90% of cancer patients and is often refractory to treatments. Alteration in gene expression is a known mechanism of cancer pain in which microRNAs (miRNAs), a class of non-coding regulatory RNAs, play a crucial role. Here, in a mouse model of cancer pain, we show that miR-124 is down-regulated in the spinal cord, the first relay of the pain signal to the brain.
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