Publications by authors named "Alexandre Bourdiol"
Purpose: Tranexamic acid (TXA) is the most widely prescribed antifibrinolytic for active bleeding or to prevent surgical bleeding. Despite numerous large multi-center randomized trials involving thousands of patients being conducted, TXA remains underutilized in indications where it has demonstrated efficacy and a lack of harmful effects. This narrative review aims to provide basic concepts about fibrinolysis and TXA's mode of action and is focused on the most recent and important trials evaluating this drug in different hemorrhagic situations.
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- A multicentric study analyzed the prevalence and risk factors of persistent pain in patients who stayed in an ICU for 48 hours or more, revealing that 47.7% experienced significant pain three months post-admission.
- Key risk factors for persistent pain included being female, previous use of antidepressants, specific positioning during care, and having pain symptoms at discharge.
- Despite the high prevalence of pain, only 11.3% of patients received specialized pain management within three months, indicating a need for better pain management strategies in critical care settings.
Objective: We assessed the efficacy of a quality improvement programme to optimize the delivery of antimicrobial therapy in critically ill patients with hospital-acquired infections (HAI).
Patients And Methods: Before-after trial in a university hospital in France. Consecutive adults receiving systemic antimicrobial therapy for HAI were included.
COVID-19, steroids and other immunomodulators: The jigsaw is not complete.
Anaesth Crit Care Pain Med
December 2020
Sepsis causes inflammation-induced immunosuppression with lymphopenia and alterations of CD4+ T-cell functions that renders the host prone to secondary infections. Whether and how regulatory T cells (Treg) are involved in this postseptic immunosuppression is unknown. We observed in vivo that early activation of Treg during Staphylococcus aureus sepsis induces CD4+ T-cell impairment and increases susceptibility to secondary pneumonia.
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- - This study investigates a quality improvement program designed to enhance neurological recovery in spinal cord injury (SCI) patients in an intensive care unit (ICU), focusing on strategies like early tracheostomy and mobilization.
- - Results showed that the intervention phase led to significant improvements in the ASIA motor score (a measure of neurological function) at discharge compared to before the program was implemented, indicating better recovery outcomes for patients.
- - One year post-trauma, patients who participated in the intervention exhibited greater neurological improvements than those in the control group, suggesting the benefits of early in-ICU rehabilitation for SCI patients.