Publications by authors named "Alexandre Atfield"
Article Synopsis
- Cbl-b is an E3 ubiquitin ligase that influences T cell activation and autoimmunity, acting as a threshold controller for T cell responses.
- The absence of Cbl-b can mimic CD28 costimulation, enhancing Ig class switching and germinal center formation in specific mouse models during viral challenges.
- Despite improved antiviral immunity and follicular dendritic cell organization with Cbl-b loss, germinal center formation remains dependent on CD28, underscoring distinct regulatory pathways for immune response components.
