Publications by authors named "Alexandre Aillerie"
Article Synopsis
- Researchers synthesized three series of indeno[1,2-c]isoquinolines with a ferrocenyl component to explore their effects on DNA interactions and cancer cell inhibition.
- The ferrocenyl was strategically placed either as a linker between nitrogen atoms or at the end of a carbon chain to assess its influence on topoisomerase I and II inhibition.
- Results indicated that the ferrocenyl addition improved topoisomerase II inhibition, and many compounds exhibited significant growth inhibition against the MDA-MB-231 breast cancer cell line, with IC50 values in the micromolar range.
The first enantioselective synthesis of 4-aza-podophyllotoxin derivatives by partial transfer hydrogenation of lactone-fused quinolines was achieved using a chiral Brønsted acid catalyst. This reaction was extended to a large scope of substrates with good yields and enantioselectivities.
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