Multicenter stability of resting state fMRI in the detection of Alzheimer's disease and amnestic MCI.

Background: In monocentric studies, patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia exhibited alterations of functional cortical connectivity in resting-state functional MRI (rs-fMRI) analyses. Multicenter studies provide access to large sample sizes, but rs-fMRI may be particularly sensitive to multiscanner effects.

Methods: We used data from five centers of the "German resting-state initiative for diagnostic biomarkers" (psymri.