Translational regulation and deregulation in erythropoiesis.

Translational regulation plays a critical role in erythropoiesis, as it reflects the translational needs of enucleated mature erythroid cells in the absence of transcription and the large translational demands of balanced globin chain synthesis during erythroid maturation. In addition, red blood cells need to respond quickly to changes in their environment and the demands of the organism. Translational regulation occurs at several levels in erythroid cells, including the differential utilization of upstream open reading frames during differentiation and in response to signaling and the employment of RNA-binding proteins in an erythroid cell-specific fashion.

A triazine di(carboxy)porphyrin dyad versus a triazine di(carboxy)porphyrin triad for sensitizers in DSSCs.

Two porphyrin-chromophores, i.e. triad PorZn-(PorCOOH)(2)-(piper)2 (GZ-T1) and dyad (PorZn)(2)-NMe2 (GZ-T1), have been synthesized and their photophysical and electrochemical properties have been investigated.