Publications by authors named "Alexandra V Yingling"
The yeast-encapsulated orange oil (YEOO) is a novel larvicide under development against vector mosquitoes. Despite its efficiency against Aedes aegypti (L.) in small scale experiments, its applicability in vector control can be influenced by other effects on mosquito behaviour or physiology.
View Article and Find Full Text PDFEpidemiological data across the United States of America illustrate health disparities in COVID-19 infection, hospitalization, and mortality by race/ethnicity. However, limited information is available from prospective observational studies in hospitalized patients, particularly for American Indian or Alaska Native (AI/AN) populations. Here, we present risk factors associated with severe COVID-19 and mortality in patients (4/2020-12/2021, n = 475) at the University of New Mexico Hospital.
View Article and Find Full Text PDFBackground: Yeast-encapsulated orange oil (YEOO) is a novel, ingestible larvicide that combines the benefits of a low-cost essential oil with yeast, an attractive food source for mosquito larvae. In this work, we investigated the underlying mechanisms of action associated with YEOO ingestion by Aedes aegypti larvae.
Methods: Aedes aegypti third-stage larvae (L3) were treated with sublethal or lethal concentrations of YEOO.
Article Synopsis
- Epidemiological data show significant health disparities in COVID-19 outcomes based on race/ethnicity in the U.S., with particularly alarming figures for American Indian or Alaska Native (AI/AN) populations.
- In a study of 94 hospitalized COVID-19 patients, viral loads (VLs) in blood were closely linked to disease severity, with those in the AI/AN group experiencing more severe illness despite similar pre-existing health conditions.
- The AI/AN participants had longer hospital stays and higher viral loads, indicating a strong correlation between elevated blood viral levels and severe COVID-19, especially within this group.
Background: On March 11, 2020, the New Mexico Governor declared a public health emergency in response to the COVID-19 pandemic. The New Mexico medical advisory team contacted University of New Mexico (UNM) faculty to form a team to consolidate growing information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease to facilitate New Mexico's pandemic management. Thus, faculty, physicians, staff, graduate students, and medical students created the "UNM Global Health COVID-19 Intelligence Briefing.
View Article and Find Full Text PDFAs severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has surged across the globe, great effort has been expended to understand mechanisms of transmission and spread. From a hospital perspective, this topic is critical to limit and prevent SARS-CoV-2 iatrogenic transmission within the healthcare environment. Currently, the virus is believed to be transmitted primarily through respiratory droplets, but a growing body of evidence suggests that spread is also possible through aerosolized particles and fomites.
View Article and Find Full Text PDFArticle Synopsis
- Convalescent plasma (CP) therapy was studied for its effectiveness in treating COVID-19, specifically looking at neutralizing antibody (NAb) levels in both donors and patients.
- The study involved hospitalized COVID-19 patients receiving CP transfusions and monitored their NAb and antibody levels over 14 days, finding initially low NAb titers with no immediate impact post-transfusion.
- Results showed that while patients developed detectable NAb levels over time, the actual CP transfusion did not enhance these levels, suggesting the need for better screening of donors for higher NAb titers.