Publications by authors named "Alexandra Susana Latini"
Background: Macrophage activation plays a central role in hepatic and systemic inflammation and is involved in the pathogenesis of acute-on-chronic liver failure (ACLF).
Aims: This study aimed to investigate neopterin levels in patients admitted for acute decompensation (AD) of cirrhosis, evaluating its relationship with ACLF and prognosis.
Methods: This prospective cohort study included 205 adult subjects hospitalized for AD of cirrhosis.
Background: Anastomotic leakage is the deadliest complication of colonic procedures. Ghrelin is an orexigenic hormone with potent actions on growth hormone release and functions in the processes of growth, tissue inflammation, repair, and oxidative stress. We evaluated the hypothesis that the exogenous administration of ghrelin causes beneficial effects on the healing of colonic anastomosis.
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- The study evaluated mitochondrial respiratory chain complex enzymatic activities in frozen brain samples from patients undergoing epilepsy surgery, which provided a unique opportunity to analyze human brain tissue directly.
- It found that various intra-operative parameters, such as mean arterial blood pressure and oxygen saturation, significantly influenced these enzymatic activities in different brain regions like the middle temporal neocortex, amygdala, and hippocampus.
- The research highlights the importance of controlling multiple factors, including seizure timing and sample storage, to reduce biases in future studies using human brain samples from elective neurosurgeries.
Design and synthesis of organoselenium compounds with high thiol peroxidase (TPx) and low thiol oxidase (TOx) activities have been a difficult task and remains a synthetic-activity relationship dilemma. In this regard we are reporting for the first time a detail experimental data (both in vitro and in vivo) about the anti-oxidant and toxicological profile of an Imine (-N) containing organoselenium compound (Compound A). The TPx activity of Compound A was significantly higher than diphenyl diselenide (DPDS).
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