Publications by authors named "Alexandra Sotelo"
Article Synopsis
- The research into TREM2, a gene linked to Alzheimer's disease (AD), has advanced our understanding of how microglia, the brain's immune cells, respond to the disease.
- Using CRISPR-modified stem cells, scientists discovered that deleting TREM2 negatively affects microglial survival and their ability to clear harmful substances like amyloid-beta.
- Single-cell analysis of human microglia showed a reduced response typical in AD, indicating that TREM2 plays significant roles in both normal and disease-specific functions of these cells in the context of Alzheimer's.
