Publications by authors named "Alexandra Ritts"
Background: Proteasome inhibitors used in the treatment of multiple myeloma act primarily through the disruption of intrinsic cellular protein quality maintenance, resulting in proteotoxic stress, cellular dysfunction, and, ultimately, cell death. We assessed whether evidence has shown off-target myocardial dysfunction related to the administration of bortezomib-based chemotherapy for multiple myeloma.
Patients And Methods: Patients aged 18 to 70 years who were free of significant cardiovascular disease were included.
Article Synopsis
- Cardiac amyloidosis is a complicated condition that needs careful assessment and suspicion for proper diagnosis and treatment.
- It affects multiple organ systems and can present with various confusing symptoms, making it challenging to identify.
- Diagnosis involves physical exams, cardiac biomarkers, noninvasive tests, and possibly a biopsy, with genetic testing being essential to determine the specific type of amyloidosis.