Colibactin-Producing Induce the Formation of Invasive Carcinomas in a Chronic Inflammation-Associated Mouse Model.

Background: producing the genotoxin colibactin (CoPEC or colibactin-producing ) abnormally colonize the colonic mucosa of colorectal cancer (CRC) patients. We previously showed that deficiency of autophagy in intestinal epithelial cells (IECs) enhances CoPEC-induced colorectal carcinogenesis in mice. Here, we tested if CoPEC trigger tumorigenesis in a mouse model lacking genetic susceptibility or the use of carcinogen.