Publications by authors named "Alexandra R Fouts"
Article Synopsis
- * Researchers conducted an epigenome-wide association study involving DNA methylation patterns across 406,365 sites in immune cells from 52 twin pairs, revealing significant differences in those affected by T1D compared to their healthy twins and unrelated individuals.
- * The identified differentially variable CpG positions (DVPs) are stable over time, linked to key regulatory elements, and highlight immune cell pathways, suggesting that epigenetic changes may start to occur after birth and could play a role in T1D pathogenesis.
Objective: We evaluated a novel electrochemiluminescent assay for insulin/proinsulin autoantibodies (ECL-IAA) as a new marker of the onset of islet autoimmunity and as a predictor of type 1 diabetes.
Research Design And Methods: The Diabetes Autoimmunity Study in the Young (DAISY) prospectively follows children at increased genetic risk for development of islet autoimmunity (defined as presence of autoantibodies to insulin, GAD65, IA-2, or zinc transporter 8 [ZnT8]) and type 1 diabetes (general population of children and first-degree relatives). Serial serum samples from subjects who progressed to type 1 diabetes and who had their first islet autoantibodies measured by age 18 months (N = 47) were tested using ECL-IAA.