Synthesis and characterization of novel radiopaque poly(allyl amine) nanoparticles.

Contrast agents are currently used in a variety of diagnostic imaging techniques, including computer tomography for early cancer detection. Radiopaque nanoparticles have recently been proposed as an alternative method to traditional contrast agents that may allow for long-term image tracking. The aim of this study was the preparation and characterization of aqueous suspensions of radiopaque nanoparticles made of poly(allyl amine) derivatives.

Elaboration of radiopaque iodinated nanoparticles for in situ control of local drug delivery.

Drug delivery systems can benefit from intrinsic radiopacity as this property will allow following up the diffusion path of the nanoparticles containing the therapeutic drug after their local administration. Herein, we report the synthesis of iodinated derivatives of cellulose acetate (CA) and their formulation into aqueous radiopaque nanoparticle suspensions. Modification and purification of CA with mono- or tri-iodobenzoyl chloride were characterized by NMR spectroscopy and elemental analysis of iodine.