Arcopilins: A New Family of Biofilm Disruptors from the Soil Fungus .

Biofilms represent a key challenge in the treatment of microbial infections; for instance, causes chronic or fatal infections by forming biofilms on medical devices. Herein, the fungus was found to produce a novel family of PKS-NRPS metabolites that are able to disrupt preformed biofilms of . Arcopilins A-F (-), tetramic acids, and arcopilin G (), a 2-pyridone, were elucidated using HR-ESI-MS and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy.