An enzyme derivatized polydimethylsiloxane (PDMS) membrane for use in membrane introduction mass spectrometry (MIMS).

Membrane introduction mass spectrometry (MIMS) provides direct measurement of volatile and semivolatile analytes in condensed and gas-phase samples without sample preparation steps. Although MIMS has numerous advantages that include direct, on-line, real-time analysis with low detection limits, current applications of MIMS are predominantly limited to volatile and semivolatile analytes that permeate hydrophobic membranes (e.g.