Publications by authors named "Alexandra Morin"
Article Synopsis
- - Immune effector cell-associated hematotoxicity (ICAHT) is a significant and common side effect following CAR-T-cell therapy, particularly impacting patient recovery and health.
- - The article discusses three cases where patients experienced severe ICAHT after receiving axicabtagene-ciloleucel (axi-cel) for diffuse large B-cell lymphoma, characterized by an increase in a specific type of lymphocyte in the bone marrow.
- - Treatment with low-dose steroids successfully resolved the cytopenias (low blood cell counts) without harming the effectiveness of the cancer treatment.
Background: Albumin has potential endothelial protective effects through antioxidant and anti-inflammatory properties. However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.
Methods: Bi-centric prospective study included patients with sepsis with or without shock and prolonged CRT > 3 s despite initial resuscitation.
Objectives: Mean arterial hypotension between 55 and 65 mm Hg could be tolerated safely in the absence of tissue hypoperfusion, but the consequences on fluid balance and kidney function remain unknown.
Design: During a 1-year period, we retrospectively collected data of consecutive septic patients admitted for sepsis with a mean arterial pressure (MAP) less than 65 mm Hg despite fluid resuscitation.
Setting: Medical 18-bed ICU in a tertiary teaching hospital.