Topical application of ozonated sunflower oil accelerates the healing of lesions of cutaneous leishmaniasis in mice under meglumine antimoniate treatment.

Besides being scarce, the drugs available for treating cutaneous leishmaniasis have many adverse effects. Ozone is an option to enhance the standard treatment due to the wound-healing activity reported in the literature. In this study, we evaluated the efficiency of ozonated sunflower oil as an adjuvant in treating cutaneous lesions caused by Leishmania amazonensis.

Human MHC class I molecule, HLA-A2.1, mediates activation of CD8 T cell IFN-γ production and the T cell-dependent protection against reactivation of cerebral infection.

To examine whether the HLA-A2.1, one of the most common MHC class I molecules in humans, activates the protective immunity against reactivation of cerebral infection with , HLA-A2.1-transgenic and wild-type (WT) mice were infected and treated with sulfadiazine to establish chronic infection in their brains.

Leishmanicidal, Trypanocidal and Antioxidant Activity of Amyrin-Rich Extracts from Cambess.

Aims: This study aimed to characterize and evaluate leishmanicidal and trypanocidal action as well as cytotoxicity on macrophages and antioxidant ability of extracts, obtained by supercritical CO and ultrasound-assisted extractions of Uvaia () leaves.

Methods: Leaves from were submitted to supercritical CO (E1) and ultrasound-assisted (E2) extractions. The characterization of extracts was done using GC-MS and HPLC.