Publications by authors named "Alexandra Mederle"
: Sodium butyrate (NaB) is a potent modulator of cancer-related gene networks. However, its precise mechanisms of action and effects at elevated doses remain insufficiently explored. This study investigated the impact of NaB at physiologically relevant doses on key cellular metrics (viability, confluence, cell number, morphology, nuclear integrity) and a comprehensive set of apoptosis and proliferation regulators (including underexplored genes) in colorectal cancer (CRC) cells.
View Article and Find Full Text PDFDiabetes is a complex global healthcare burden involving multiple organ systems with its prevalence on the rise. SGLT2 inhibitors enhance glucose excretion. The objective of our literature review was to determine the association between cutaneous adverse drug reactions (CADRs) and the use of SGLT2 inhibitors.
View Article and Find Full Text PDFPazopanib, a multi-targeted tyrosine kinase inhibitor, has been explored for its efficacy in treating various subtypes of thyroid cancer, including differentiated thyroid carcinoma (DTC), medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). This systematic review assesses the efficacy and safety of pazopanib, focusing on the progression-free survival (PFS), overall survival (OS), and response rates and adverse events. A comprehensive search was conducted in databases including PubMed, Scopus, and Web of Science up to October 2024 to identify randomized controlled trials and phase II clinical trials that investigated the use of pazopanib in thyroid cancer.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined the effects of gut microbiota-targeted interventions like probiotics and dietary changes on metabolic health in individuals with diabetes, obesity, and metabolic syndrome, focusing on parameters like glucose and cholesterol levels.
- - A systematic review of 41 clinical trials found that these interventions significantly lowered fasting glucose, HbA1c, cholesterol, and triglycerides, with probiotics and synbiotics showing the best results while FMT had variable outcomes.
- - Short-duration interventions caused quick changes in gut bacteria but limited metabolic benefits, whereas longer interventions led to greater improvements in metabolic health.
Particularities of a Cardiac Amorphous Left Ventricular Tumor in a Patient with Coronary Artery Disease-Diagnostic and Therapeutic Challenges: A Case Report and Literature Review.
J Clin Med
October 2024
Article Synopsis
- * Research for this case involved reviewing scientific literature from various sources between 2020 and 2024, revealing limited information on CATs, with only 16 reported cases available and varying postoperative outcomes.
- * Despite being a young male without certain risk factors, the patient developed a larger LV CAT and was observed for 3 years post-removal, supporting literature claims that complete removal reduces chances of recurrence, although CATs carry a risk of embolization.
Comparison of One-Year Post-Operative Evolution of Children Born of COVID-19-Positive Mothers vs. COVID-19-Negative Pregnancies Having Congenital Gastrointestinal Malformation and Having Received Proper Parenteral Nutrition during Their Hospital Stay.
Pediatr Rep
September 2024
Article Synopsis
- The study investigates the long-term health effects on infants born to mothers with COVID-19, focusing on those with congenital gastrointestinal malformations (CGIMs) who required surgery.
- A total of 41 patients were analyzed, divided into two groups based on their mothers' COVID-19 status, and a one-year follow-up assessed their growth and developmental milestones.
- Results showed that infants from COVID-19-positive pregnancies (Group 1) had significantly lower height and weight than those from non-COVID-19 pregnancies (Group 2), with a notable prevalence of antibiotic use and malabsorption syndrome in Group 1.
Introduction: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by significant autoantibodies, particularly targeting nuclear antigens. SLE pathogenesis involves genetic, environmental, and hormonal factors. The disease course includes flares and remission and involves various organs.
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