Publications by authors named "Alexandra McCraw"
Antibodies used for cancer therapy are monoclonal IgGs, but tumor-targeting IgE antibodies have shown enhanced effector cell potency against cancer in preclinical models. Research-grade recombinant IgE antibodies have been generated and studied for several decades. The recent Phase 1 clinical trial of the first-in-class MOv18 IgE, however, necessitated the inaugural process development and scaled manufacture of a recombinant IgE to clinical quality standards.
View Article and Find Full Text PDFArticle Synopsis
- The study reviews the role of glycosylation in human IgE (Immunoglobulin E) and how it affects its structure, function, and relation to diseases, especially allergies.
- It emphasizes that despite inconsistent findings from various studies, there is evidence of different glycosylation patterns in allergic vs. healthy individuals and their functional implications in allergic reactions.
- The review suggests that certain glycosylation changes could lead to potential therapeutic targets and underscores the need for improved research methods to further investigate these effects.
Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE-mediated diseases and glioma. Allergic disease stems from a Th2-biased immune response to allergens in predisposed atopic individuals.
View Article and Find Full Text PDF