Publications by authors named "Alexandra Maulden"
In early June 2021, the U.S. Food and Drug Administration ("FDA") granted Accelerated Approval to Aducanumab ("Aduhelm") for treating Alzheimer's disease.
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- The study focused on the challenges of diagnosing Lyme disease-related arthritis in children, particularly given the delayed results from conventional tests, leading to unnecessary procedures.
- A C6 peptide enzyme immunoassay (EIA) test was evaluated for its effectiveness in guiding initial management of these cases among 911 children.
- The C6 EIA test showed a 100% sensitivity and 94.2% specificity for diagnosing Lyme arthritis, suggesting it could be a reliable tool to help clinicians differentiate between Lyme arthritis and septic arthritis, minimizing invasive interventions.
Background: Variability in 2-tier Lyme disease test results according to the specific first-tier enzyme immunoassay (EIA) in children has not been examined rigorously. In this study, we compared paired results of clinical 2-tier Lyme disease tests to those of the C6 peptide EIA followed by supplemental immunoblotting (C6 2-tier test).
Methods: We performed a prospective cohort study of children aged ≥1 to ≤21 years who were undergoing evaluation for Lyme disease in the emergency department at 1 of 6 centers located in regions in which Lyme disease is endemic.
Background: Clinicians utilize inflammatory markers, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), to identify febrile children who may have an occult serious illness or infection.
Objectives: Our objective was to determine the relationship between invasive bacterial infections (IBIs) and CRP and ESR in febrile children.
Methods: We performed a retrospective cross-sectional study of 1460 febrile children <21 years of age, who presented to a single Emergency Department (ED) between 2012 and 2014 for evaluation of fever of <14 days' duration, who had both CRP and ESR obtained.
Knowing the frequency of positive Lyme disease serology in children without signs of infection facilitates test interpretation. Of 315 asymptomatic children from Lyme disease endemic regions, 32 had positive or equivocal C6 enzyme-linked immunoassays, but only 5 had positive IgG or IgM supplemental immunoblots (1.6%; 95% confidence interval: 0.
View Article and Find Full Text PDFBackground: To make initial management decisions, clinicians must estimate the probability of Lyme disease before diagnostic test results are available. Our objective was to examine the accuracy of clinician suspicion for Lyme disease in children undergoing evaluation for Lyme disease.
Methods: We assembled a prospective cohort of children aged 1 to 21 years who were evaluated for Lyme disease at 1 of the 5 participating emergency departments.