Publications by authors named "Alexandra M Thornock"
Article Synopsis
- Dysregulation of TGFb-related signaling pathways is a common feature in melanoma, leading to unique gene expression patterns in advanced stages of the disease.
- Researchers identified a specific TGFb enhancer active in melanoma cells, revealing that it is not present in normal or early melanoma cells but shows distinct expression in advanced melanomas.
- The study suggests that chronic TGFb signaling alters macrophage behavior and emphasizes the importance of developing biomarkers to improve patient responses to TGFb inhibitors.
