Publications by authors named "Alexandra M Mangion"
Article Synopsis
- Lysine biosynthesis in plants uses the diaminopimelate pathway, starting with the enzyme dihydrodipicolinate synthase (DHDPS), which is regulated by the end product, lysine.
- In Arabidopsis thaliana, knockouts of two DHDPS isoforms show distinct phenotypes, even though they are over 85% identical in sequence.
- The study found that AtDHDPS1 is significantly more sensitive to lysine than AtDHDPS2 due to subtle structural differences, particularly in a key residue, impacting its allosteric regulation and lysine dissociation.
