Publications by authors named "Alexandra M Clarke"
Article Synopsis
- The study investigates how social inequalities at both the individual and community levels impact functional disability in patients with early inflammatory polyarthritis over a three-year period.
- Researchers analyzed data from 1,393 patients, examining the relationship between their health outcomes (measured by the Health Assessment Questionnaire) and their socioeconomic status, determined by area deprivation and personal social class.
- Results show that individuals from more deprived areas and lower social classes experienced worse health outcomes, suggesting that both personal circumstances and residential environment independently affect the progression of the disease.
Objective: To assess immunologically relevant outcomes in a cohort of rheumatoid arthritis (RA) patients with prolonged therapy-induced lymphopenia.
Methods: Morbidity (infection or malignancy) and mortality were assessed in 53 RA patients who were treated with the lymphocytotoxic monoclonal antibody alemtuzumab between 1991 and 1994. Data were obtained by interview, medical record review, and Office for National Statistics mortality monitoring.
Background: Primary care consultation data are an important source of information on morbidity prevalence. It is not known how reliable such figures are.
Aim: To compare annual consultation prevalence estimates for musculoskeletal conditions derived from four general practice consultation databases.
Objective: Renal involvement is a major complication of systemic lupus erythematosus (SLE) and is a strong determinant of morbidity and mortality. There have been no previous studies of the epidemiology of lupus nephritis. Our aim was to establish the prevalence and incidence of biopsy-proven lupus nephritis in the northwest of England in 2001 and to examine the influence of age, sex, and ethnicity.
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