Publications by authors named "Alexandra Lengyel"

Background: Cardiovascular failure is recognized as a common final pathway at the end of life but there is a paucity of data describing terminal arrhythmias.

Aim: We aimed to describe arrhythmias recorded peri-mortem in critically ill patients.

Study Design: We enrolled intensive care unit patients admitted to two tertiary Canadian medico-surgical centres.

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Background: Atrial fibrillation (AF) is often detected for the first time in patients who are hospitalized for another reason. Long-term risks for AF recurrence in these patients are unclear.

Objective: To estimate risk for AF recurrence in patients with new-onset AF during a hospitalization for noncardiac surgery or medical illness compared with a matched population without AF.

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Aims: Electrical cardioversion is commonly used to restore sinus rhythm in patients with atrial fibrillation (AF), but procedural technique and clinical success vary. We sought to identify techniques associated with electrical cardioversion success for AF patients.

Methods And Results: We searched MEDLINE, EMBASE, CENTRAL, and the grey literature from inception to October 2022.

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Article Synopsis
  • - The study aimed to evaluate how different anti-arrhythmic drugs (AADs) affect the restoration and maintenance of sinus rhythm in patients with atrial fibrillation (AF) undergoing electrical cardioversion.
  • - A systematic review and network meta-analysis of 28 randomized controlled trials found that Class III AADs and amiodarone significantly improved the acute restoration of sinus rhythm compared to no treatment or rate control.
  • - Amiodarone was shown to be the most effective in maintaining sinus rhythm long-term after electrical cardioversion, while Class Ic and Class III AADs also proved effective, albeit to a lesser extent.
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Unlabelled: To estimate the incidence of new-onset atrial fibrillation in critically ill patients.

Design: Prospective cohort.

Setting: Medical-surgical ICU.

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Background: Delirium is common after cardiac surgery and is associated with adverse outcomes. Perioperative benzodiazepine use is associated with delirium and is common during cardiac surgery, which may increase the risk of postoperative delirium. We undertook a pilot study to inform the feasibility of a large randomised cluster crossover trial examining whether an institutional policy of restricted benzodiazepine administration during cardiac surgery (compared with liberal administration) would reduce delirium.

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Objective: We conducted a meta-analysis to estimate the risk of adverse events, life expectancy, and event-free life expectancy after the Ross procedure in adults.

Methods: We searched databases for reports evaluating the Ross procedure in patients aged more than or equal to 16 years of age. A microsimulation model was used to evaluate age- and gender-specific life expectancy for patients undergoing the Ross procedure.

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Importance: Vasopressin is an alternative to catecholamine vasopressors for patients with distributive shock-a condition due to excessive vasodilation, most frequently from severe infection. Blood pressure support with a noncatecholamine vasopressor may reduce stimulation of adrenergic receptors and decrease myocardial oxygen demand. Atrial fibrillation is common with catecholamines and is associated with adverse events, including mortality and increased length of stay (LOS).

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Introduction: Life expectancy in young adults undergoing mechanical or bioprosthetic aortic valve replacement (AVR) may be reduced by up to 20 years compared to age matched controls. The Ross procedure is a durable, anticoagulation-sparing alternative. We performed a systematic review and meta-analysis to compare the valve hemodynamics of the Ross procedure versus other AVR.

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