Modeling Ecological Constraints on a CO Pipeline Network.

Carbon capture, utilization, and storage (CCUS) are a critical set of strategies to decarbonize the industrial and power sectors and to mitigate global climate change. Pipeline infrastructure connecting CO sources and sinks, if not planned strategically, can cause environmental and social impacts by disturbing local landscapes. We investigated the impacts of these considerations on optimal CO pipeline routing and sink locations by modifying and leveraging an open-source CCUS infrastructure model, We expanded from a cost-minimizing to a multiobjective framework, explicitly incorporating environmental protection objectives.

Polymeric Nanocarrier Formulations of Biologics Using Inverse Flash NanoPrecipitation.

The encapsulation of water-soluble therapeutics and biologics into nanocarriers to produce novel therapeutics has been envisioned for decades, but clinical translation has been hampered by complex synthesis strategies. The methods that have been developed are often limited by poor encapsulation efficiency/loading or complex processing to achieve therapeutic loadings high enough to be medically relevant. To address this unmet need, we introduce a solubility-driven self-assembly process to form polymeric nanocarriers comprising a biologic in a hydrophilic core, encapsulated by a poly(lactic acid) shell, and stabilized by a poly(ethylene glycol) brush.