Publications by authors named "Alexandra L Hanlon"

Aim: To evaluate the implementation of the Transitional Care Model (TCM), an evidence-based, advanced practice registered nurse-led multi-component intervention, as part of a randomised controlled trial during the first year of the COVID-19 pandemic.

Design: Parallel convergent mixed-methods approach.

Methods: Data for this study were collected between June 2020 and February 2021.

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Poor sleep health has been previously documented in veterinary medical students. However, it is not known how universal or widespread this problem is. This study evaluated Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) scores to measure sleep health among students at seven colleges of veterinary medicine in the United States (US).

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Medical researchers are increasingly prioritizing the inclusion of underserved communities in clinical studies. However, mere inclusion is not enough. People from underserved communities frequently experience chronic stress that may lead to accelerated biological aging and early morbidity and mortality.

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Overconsumption of ultra-processed foods (UPFs), which are linked with adverse health outcomes, is a growing public health concern. UPFs deliver highly bioavailable calories rapidly, which may contribute to their reinforcing potential and drive overconsumption. Our primary aim is to test the role of speed of nutrient availability on reward learning.

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Article Synopsis
  • Data-intensive research seeks to enhance healthcare delivery, decision-making, and patient outcomes, relying on quantitative scientists like biostatisticians and epidemiologists to transform data into actionable health knowledge.
  • Academic health centers have established centralized Quantitative Science Units focused on the professional growth of quantitative scientists and high-quality research output, but lack clear guidelines on team formation and management.
  • A working group of Quantitative Science Unit leaders from six institutions aims to share best practices and tools for developing, managing, and evaluating Quantitative Science Teams, thereby improving research collaboration and adapting to changing research demands.
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We overview of our whole room indirect calorimeter (WRIC), demonstrate validity and reliability of our WRIC, and explore a novel application of Bayesian hierarchical modeling to assess responses to small carbohydrate loads. To assess WRIC validity seven gas infusion studies were performed using a gas blender and profiles designed to mimic resting and postprandial metabolic events. Sixteen participants underwent fasting and postprandial measurements, during which they consumed a 75-kcal drink containing sucrose, dextrose, or fructose in a crossover design.

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Objectives: Research on links between social, geographic, and cultural determinants of health has been thwarted by inadequate measures of culture. The purpose of this study was to improve the measurement of community culture, defined as shared patterns of attitudes and behaviors among people within a neighborhood that distinguish it from others, and to examine dimensions of culture, independent of socioeconomic and demographic factors, and their relationships with health.

Study Design: A survey research design with correlational analyses was used.

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Objective: To assess differences in longitudinal profiles for 30-day risk-adjusted readmission rates in skilled nursing facilities (SNFs) associated with Penn Medicine's Lancaster General Hospital (LGH) that implemented an interventional analytics (IA) platform vs other LGH facilities lacking IA vs other SNFs in Pennsylvania vs facilities in all other states.

Study Design: Retrospective longitudinal analysis of CMS readmissions data from 2017 through 2022, and cross-sectional analysis using CMS quality metrics data.

Methods: CMS SNF quality performance data were aggregated and compared with risk-adjusted readmissions by facility and time period.

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There has been a rapid shift in the modern food environment towards increased processing in foods consumed in the United States (US) and globally. The NOVA system (not an acronym) for classifying food on degree of processing currently has the most empirical support. Consumption of foods in the NOVA 4 category, ultra-processed foods (UPF), is a risk factor for a host of poor health outcomes including heart disease, stroke, and cancer.

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This study sought to investigate the relationship between antibiotic exposure and subsequent risk of psychiatric disorders. This retrospective cohort study used a national database of 69 million patients from 54 large healthcare organizations. We identified a cohort of 20,214 (42.

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Objective: To examine family medicine (FM) and obstetrician-gynecologist (OB/GYN) residents' experiences with CenteringPregnancy (CP) group prenatal care (GPNC) as a correlate to perceived likelihood of implementing CP in future practice, as well as knowledge, level of support, and perceived barriers to implementation.

Methods: We conducted a repeated cross-sectional study annually from 2017 to 2019 with FM and OB/GYN residents from residency programs in the United States licensed to operate CP. We applied adjusted logistic regression models to identify predictors of intentions to engage with CP in future practice.

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Objective: To provide an overview of our whole room indirect calorimeter (WRIC), demonstrate validity and reliability of our WRIC, and explore a novel application of Bayesian hierarchical modeling to assess responses to small carbohydrate loads.

Methods: Seven gas infusion studies were performed using a gas blender and profiles designed to mimic resting and postprandial metabolic events to assess WRIC validity. In a crossover design, 16 participants underwent fasting and postprandial measurements, during which they consumed a 75-kcal drink containing sucrose, dextrose, or fructose.

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Article Synopsis
  • The text discusses the evolving role of collaborative biostatistics units in academic health centers (AHCs) across the U.S., which provide centralized resources and infrastructure for researchers in various fields or within specific disciplines like cancer.
  • A survey of 129 leaders revealed that most are over 45, hold doctoral degrees, and typically have primary appointments in medical schools, with key metrics for career advancement including NIH grant funding and authorship in peer-reviewed journals.
  • The findings offer a benchmark for evaluating collaboration models, serving as a useful reference for institutional administrators looking to enhance or restructure quantitative support infrastructures.
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Background: Almost 60% of adults with amnestic mild cognitive impairment (aMCI) have obstructive sleep apnea (OSA). Treatment with continuous positive airway pressure (CPAP) may delay cognitive decline, but CPAP adherence is often suboptimal. In this study, we report predictors of CPAP adherence in older adults with aMCI who have increased odds of progressing to dementia, particularly due to Alzheimer's disease.

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Vaccine hesitancy amongst healthcare workers (HCWs) has been a major challenge throughout the COVID-19 pandemic. While many studies have identified HCW characteristics and specific attitudes associated with COVID-19 vaccine hesitancy, researchers are still working towards developing a holistic understanding of the psychological constructs that influence COVID-19 vaccine decision-making in this population. Between 15 March and 29 March 2021, we distributed an online survey assessing individual characteristics and vaccine-related perceptions to employees of a not-for-profit healthcare system in Southwest Virginia (N = 2459).

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  • Class IV dental diode lasers were studied as a nonsurgical treatment for periodontal pockets in dogs, aiming to reduce pocket depth in a specialty veterinary dental practice.
  • A total of 12 dogs with periodontal pockets between 3-6 mm underwent closed root planing and laser therapy, with significant improvement observed: average pocket depth decreased from 3.35 mm to 0.59 mm after treatment.
  • Statistical analysis showed a mean reduction of 2.63 mm in pocket depth (highly significant), but no notable differences based on the type of periodontal pocket were found.
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  • This manuscript outlines an experiential learning program designed for future collaborative biostatisticians at Duke University School of Medicine, integrating the efforts of the BERD Methods Core and the Master of Biostatistics program.
  • The program, known as the BERD Core Training and Internship Program (BCTIP), has successfully trained over 80 students to collaborate with various teams in the medical school environment.
  • The text discusses the training program's setting, its experiential learning model, program structure, and valuable lessons learned from its implementation.
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  • Digital amputation is commonly performed for infections and necrosis in high-risk patients, but there's limited data on its long-term outcomes and survivability.
  • In a study analyzing 484 digital amputations over ten years, those performed due to infection or necrosis had a significantly higher revision rate (34%) and mortality risk compared to trauma-related amputations.
  • The findings highlight that patients with additional health issues like diabetes or PVD face even greater risks, with 2, 5, and 10-year survival rates significantly lower than the general population.
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This study protocol describes the conceptual framework, design, and methods being employed to evaluate the implementation of the Transitional Care Model (TCM) as part of a randomized controlled trial. The trial, designed to examine the health and cost outcomes of at-risk hospitalized older adults, is being conducted in the context of the COVID-19 pandemic. This parallel study is guided by the Practical, Robust, Implementation and Sustainability Model (PRISM) and uses a fixed, mixed methods convergent parallel design to identify challenges encountered by participating hospitals and post-acute and community-based providers that impact the implementation of the TCM with fidelity, strategies implemented to address those challenges and the relationships between challenges, strategies, and rates of fidelity to TCM's core components over time.

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The purpose of the current in-depth qualitative study was to explore the experiences of older adults and family caregivers in primary care. Twenty patients and caregivers from six Comprehensive Primary Care Plus (CPC+) practices' Patient and Family Advisory Councils within a large academic health system participated in telephone interviews from December 2018 to May 2019. Participants were mostly women (60%), with an average age of 71 years and nine chronic conditions.

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Goal: The objective of this retrospective, observational study was to assess the mediating effect of medical complexity on the relationship between social vulnerability and four acute care resource use outcomes-number of hospitalizations, emergency department (ED) visits, observation stays, and total visits. Such information may help healthcare managers better anticipate the effects of interventions targeted to the socially vulnerable in their patient population.

Methods: Electronic health records of 147,496 adults served by 27 primary care practices in one large health system from 2015 to 2017 were used.

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The World Health Organization acknowledges quality of life (QOL) as subjectively perceived overall well-being by the individual and recognizes it as an essential construct for overall health and wellness. The purpose of this study was to examine the association of infant, environmental, and parental factors with the QOL of mothers of infants at four months post-hospital discharge from cardiac surgery. Secondary analysis of prospectively collected data from the REACH randomized clinical trial of telehealth home monitoring.

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