Publications by authors named "Alexandra K Konyukova"
Article Synopsis
- - This review analyzes mitochondrial DNA (mtDNA) mutations in colorectal cancer stem cells (CSCs) and their impact on tumor behavior and treatment strategies
- - It highlights the unique characteristics of CSCs, including their self-renewal abilities and resistance to standard therapies, while noting their significant metabolic differences and reliance on functional mitochondria
- - The article suggests new therapeutic avenues targeting mitochondrial function in CSCs and emphasizes the necessity for further research, including developing preclinical models to enhance treatment options for colorectal cancer
This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes.
View Article and Find Full Text PDFBarrett's esophagus is a widespread chronically progressing disease of heterogeneous nature. A life threatening complication of this condition is neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis, preventative measures and treatment. In this essay, we aim to stratify existing data to show specific associations between neoplastic transformation and the underlying processes which predate cancerous transition.
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