Publications by authors named "Alexandra J Straus"
Sphingolipids play key roles in membrane structure and cellular signaling. Ceramide synthase (CerS)-generated ceramide is implicated in cellular stress responses and induction of apoptosis. Ceramide and other sphingolipids are linked to the induction of ER stress response pathways.
View Article and Find Full Text PDFArticle Synopsis
- Sphingolipids are essential for membrane structure and cellular signaling, with ceramide being a key molecule in this process generated by specific enzymes called ceramide synthases (CerS).
- The small heat shock protein 27 (Hsp27) specifically interacts with and inhibits CerS1, affecting ceramide production; this interaction is crucial for understanding CerS regulation.
- Hsp27's activity influences mitochondrial function and mitophagy, highlighting its role in the cellular response to stress and its significance in managing CerS1-related processes.