Early Outcomes of Right Ventricular Pressure and Volume Overload in an Ovine Model.

Right ventricular (RV) failure is a common complication in multiple congenital heart disease (CHD), significantly increasing morbidity and mortality. Despite its impact, no therapies specifically target the failing RV. The growing population of CHD patients underscores the need to understand the pathophysiology of RV failure through preclinical research.

Significance of inflammation-related markers and histopathological features in mitral valve regurgitation.

The lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), C-reactive protein (CRP)-to-lymphocyte ratio (CLR) and fibrinogen-to-albumin ratio (FAR) are well-known indicators of the systemic inflammatory response (SIR). Less is known about the association of SIR with the echocardiographic parameters and the histopathological (HP) aspects of the mitral valve in patients who have undergone cardiac surgery to repair or replace the mitral valve. Information on serum parameters, transesophageal echocardiography findings, and HP results was obtained from 166 patients who had undergone cardiac surgery to address mitral valve regurgitation.

Umbilical cord blood collection through elective cesarean section in an ovine model - a pilot study.

Background: Despite advancements in congenital heart surgery, long-term outcomes remain challenging, with many patients developing heart failure and requiring transplants at a young age. Stem cell therapy, particularly using umbilical cord-derived mesenchymal stem cells, is emerging as a promising adjunct treatment. Adult studies suggest functional improvements, but pediatric research remains sparse.