Publications by authors named "Alexandra Ioana Trandafir"
Article Synopsis
- Non-functioning adrenal incidentalomas (NFAIs) are associated with a higher risk of glucose profile issues, especially type 2 diabetes mellitus (T2DM), though clear links to Cushing's syndrome aren't fully established.
- A comprehensive literature review analyzed 37 studies involving over 17,000 individuals, finding T2DM prevalence in NFAIs with mild autonomous cortisol secretion (MACS) ranged from 12% to 44%, with some studies showing rates as high as 45.2%.
- Comparisons between NFAIs and non-tumor controls indicated increased T2DM rates in NFAIs, and while some studies examined Cushing's syndrome, results regarding glucose profile anomalies were inconsistent.
Article Synopsis
- - Analysis focused on three key aspects of pancreas involvement in primary hyperparathyroidism (PHP): hypercalcemia-induced pancreatitis (HCa-P), MEN1-related neuroendocrine tumors (NETs), and insulin resistance, utilizing studies from PubMed between January 2020 and January 2024.
- - Findings showed that HCa-P had links to NETs and pancreatitis, with case reports revealing instances in pregnant individuals and cases of parathyroid carcinoma; MEN1-related studies indicated a high recurrence rate after surgery and significant associations among PHP and pancreatic NETs.
- - Insulin resistance analysis indicated that about one-third of adults could be prediabetic, with a notable correlation between serum calcium levels and insulin resistance
Our objective was to overview the novel aspects in the field of adrenal gland neoplasms, namely, the management of bone status with respect to primary aldosteronism (PA). In the current narrative review, a PubMed study was conducted from inception until June 2023. The inclusion criteria were: human (clinically relevant) studies of any study design (at least 10 patients per study); English papers; and the following combination of key words within the title and/or abstract: "aldosterone" AND "bone", "skeleton", "osteoporosis", "fracture", "calcium", "parathyroid", "DXA", "osteocalcin", "P1NP", "alkaline phosphatase", "bone marker", "trabecular bone score", or "FRAX".
View Article and Find Full Text PDFBone fragility is a complication of type 2 diabetes mellitus (T2DM) that has been identified in recent decades. Trabecular bone score (TBS) appears to be more accurate than bone mineral density (BMD) in diabetic bone disease, particularly in menopausal women with T2DM, to independently capture the fracture risk. Our purpose was to provide the most recent overview on TBS-associated clinical data in T2DM.
View Article and Find Full Text PDFOur aim is to update the topic of adrenal tumours (ATs) in congenital adrenal hyperplasia (CAH) based on a multidisciplinary, clinical perspective via an endocrine approach. This narrative review is based on a PubMed search of full-length, English articles between January 2014 and July 2023. We included 52 original papers: 9 studies, 8 case series, and 35 single case reports.
View Article and Find Full Text PDFOur aim is to analyse the bone profile in adults with (non-functioning) adrenal incidentalomas (AIs), specifically addressing the impact of autonomous cortisol secretion (ACS). This narrative review, based on a PubMed search from inception to February 2023 (case reports, non-ACS, and other secondary causes of osteoporosis were excluded), included 40 original studies, a total of 3046 patients with female prevalence (female:male ratio of 1921:1125), aged between 20.5 and 95.
View Article and Find Full Text PDFOur purpose is to provide new insights concerning the challenges of pituitary apoplexy in pregnancy (PAP) and the postpartum period (PAPP). This is a narrative review of the English literature using a PubMed search. The inclusion criteria were clinically relevant original studies (January 2012-December 2022).
View Article and Find Full Text PDFArticle Synopsis
- Pituitary apoplexy (PA) is a serious condition related to pituitary neuroendocrine tumors (PitNET), characterized by intratumor hemorrhage or infarction, requiring early identification and treatment to prevent life-threatening complications.
- A review of recent literature from 2012 to 2022 analyzed 194 studies involving 1452 PA patients, revealing symptoms like severe headaches, visual disturbances, and neurological issues, with notable risk factors including hypertension and diabetes.
- The analysis also identified iatrogenic risks from medications (like anticoagulants), diagnostic techniques, and surgical interventions that could contribute to PA occurrences.
Article Synopsis
- Beta-thalassemia (BTH) leads to serious health issues, including iron overload and various endocrine disorders collectively termed thalassemic endocrine disease (TED), affecting fertility, growth, and bone health.
- Research shows that one in three children under 12 with BTH has an endocrine disorder, and up to 86% of adults are affected, with age increasing risk; however, prevalence rates vary based on demographics and study definitions.
- Key issues include hypogonadism, growth hormone deficiencies, hypothyroidism, and decreased bone mineral density, often related to iron levels and treatment compliance, though some correlations remain debated among studies.
Primary hyperparathyroidism (PHPT), an endocrine condition caused by a parathyroid adenoma (PTA) in 80-85% of the cases, has shifted in the modern era to a mildly symptomatic phenotype due to the prompt recognition of hypercalcemia and to a minimally invasive surgical approach which has a curative potential. Clinical complications of PHTH are either related to high calcium or parathyroid hormone [also parathormone (PTH)] or both, while the originating tumor typically is small, without local mass effects. A distinct entity is represented by giant PTA (GPTA) which is considered at a weight of more than 3 (3.
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