Publications by authors named "Alexandra G Gadiano"
Article Synopsis
- Brain injury and inflammation lead to the release of extracellular vesicles (EVs) from astrocytes, which can trigger immune responses that worsen brain damage and hinder recovery.
- Inhibiting the enzyme neutral sphingomyelinase 2 (nSMase2) may offer a new treatment method, but existing inhibitors have limitations like low effectiveness and poor brain entry.
- A new compound, DPTIP, was found to be a strong and effective nSMase2 inhibitor that reduced EV release and related immune responses in mouse models of brain injury, showing potential for better therapeutic outcomes.
