Publications by authors named "Alexandra E Klimova"
Article Synopsis
- - This study focuses on new ionic liquids derived from imidazolium and choline containing 5-fluorouracil, exploring their effects on the structure and binding behavior with bovine serum albumin (BSA) using techniques like circular dichroism (CD) and fluorescence quenching.
- - The research investigates how the length of alkyl chains in these ionic liquids impacts their interaction with BSA and their aggregation tendencies through dynamic light scattering (DLS).
- - Results reveal that longer alkyl chains do not enhance binding to BSA, but one specific compound showed selectivity against cancer cells that regular 5-fluorouracil lacks, suggesting potential benefits in cancer treatment.
In this work, we describe the synthesis, interactions with bovine serum albumin, and cytotoxicity of new ionic liquids based on 5-fluorouracil (API-ILs) with different cations (imidazolium, choline, isoquinolinium, guanidinium). The secondary and tertiary structure of BSA in solutions with different concentrations of API-ILs was monitored by the circular dichroism (CD) technique. The addition of API-ILs does not lead to structural changes in BSA.
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