Publications by authors named "Alexandra Dubon Mercante"
Article Synopsis
- MpeR, a transcriptional regulator in Neisseria gonorrhoeae, represses the mtrF gene, which is crucial for the function of the Mtr efflux pump that helps the bacteria resist antimicrobials.
- The regulation of mpeR is influenced by iron availability, suggesting a link between iron levels and the expression of an interconnected regulatory system that modulates antibiotic resistance.
- Microarray analysis revealed that under low iron conditions, MpeR directly represses the mtrR gene, leading to increased expression of the mtrCDE efflux pump and enhancing gonococcal resistance to specific antimicrobial agents.
Neisseria gonorrhoeae is an obligate human pathogen that causes the common sexually transmitted infection gonorrhea. Gonococcal infections cause significant morbidity, particularly among women, as the organism ascends to the upper reproductive tract, resulting in pelvic inflammatory disease, ectopic pregnancy, and infertility. In the last few years, antibiotic resistance rates have risen dramatically, leading to severe restriction of treatment options for gonococcal disease.
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