Publications by authors named "Alexandra Dram"
BACKGROUNDSepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical outcomes and immunological endotyping of septic patients generally relies on using blood protein or mRNA biomarkers, or static cell phenotyping. Here, we sought to determine whether functional immune responsiveness would yield improved precision.
View Article and Find Full Text PDFBackground: We report the case of a patient with aplastic anemia and pancytopenia on immune-suppressive therapy who developed invasive pulmonary infection with mucormycosis and was treated with immune adjuvant therapy.
Case Summary: Given the patient's profound lymphopenia and progressive invasive mucor despite dual antifungal drug therapy, interleukin (IL)-7, a cytokine that induces lymphocyte activation and proliferation, was instituted and resulted in normalization of absolute lymphocyte counts and was temporally associated with clearance of fungal pathogens and resolution of clinical symptoms.
Conclusion: Patients with life-threatening fungal infections are frequently immune suppressed and immune adjuvant therapies should be considered in patients who are not responding to antifungal drugs and source control.
Background: Sepsis remains a major clinical challenge for which successful treatment requires greater precision in identifying patients at increased risk of adverse outcomes requiring different therapeutic approaches. Predicting clinical outcomes and immunological endotyping of septic patients has generally relied on using blood protein or mRNA biomarkers, or static cell phenotyping. Here, we sought to determine whether functional immune responsiveness would yield improved precision.
View Article and Find Full Text PDFArticle Synopsis
- - Multisystem inflammatory syndrome in children (MIS-C) is a severe immune response condition linked to COVID-19, causing hyperinflammation and immune dysfunction in affected kids.
- - The condition involves abnormal immune reactions, including unusual cytokine production and T cell suppression, and its understanding is continuously advancing as more COVID-19 research unfolds.
- - A thorough clinical review has been created to summarize current findings on MIS-C, including symptoms, vaccine effects, genetic factors, treatment options, and long-term outcomes, to support further studies in the area.