Publications by authors named "Alexandra Denisa Semenescu"
Background And Aims: Adenomyosis is a heterogeneous disease, which differs from patient to patient. The objective of our study was to evaluate the risk factors that influence the occurrence of adenomyosis, more precisely to highlight aspects that may be used in practice. In addition, the impact of levonorgestrel (a possible predisposing factor in the occurrence of adenomyosis) on MDA-MB-231 cells was evaluated, trying to obtain a link between adenomyosis and mammary cancer.
View Article and Find Full Text PDFIntroduction: Pregnant women manifest an increased risk of developing coagulation disorders. Unfractionated heparin (HEP) and low-molecular-weight heparin (LMWHep) are considered as selective medication in the case of pregnancy which needs anticoagulant treatment. In addition to anticoagulant properties, HEP and its derivatives manifest other properties including anti-cancer potential.
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- * In vitro tests on healthy skin cell lines showed that the hydrogels had a good biosafety profile, with no significant toxicity or harmful effects observed after exposure.
- * Additional in vivo studies on mice and chicken embryos confirmed the hydrogels' biocompatibility, but further research is necessary to assess their long-term therapeutic effects and clinical application potential.
Article Synopsis
- Chlorhexidine (CHX) is widely used as an antiseptic in dentistry and medicine, known for its strong antimicrobial properties, but concerns about its toxicity have risen.
- This study tested the toxicity of CHX digluconate at various concentrations on different human cell lines and showed that it caused significant damage to cell viability and structure in a concentration- and time-dependent manner.
- The most harmful concentrations (0.02% and 0.2%) not only reduced cell health but also caused irritation in developing eggs, highlighting the need for more research on the safety of CHX use.
Article Synopsis
- The study examined the effects of diethyl ether (GvDEE) and butanol (GvBuOH) extracts from a specific plant (L.) on A375 human malignant melanoma cells to assess their antitumor potential.
- GvDEE showed a higher antioxidant capacity and antimicrobial activity against Gram-positive bacteria compared to GvBuOH, which had no antimicrobial effects.
- Both extracts significantly reduced the viability of A375 cells, with GvDEE causing 69% reduction at a certain dose, and both extracts led to apoptosis, indicating their potential as treatments for skin cancer.
species are used worldwide for their antioxidant, antibacterial, antifungal, and antiparasitic properties. Although this plant has demonstrated its antitumor properties on various types of cancer, its biological activity on cutaneous melanoma has not been established so far. Therefore, the present study was designed to investigate the phytochemical profile of two extracts of L.
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- - Malignant melanoma is a major health concern, particularly in developing countries, highlighting the urgent need for new treatments for cases resistant to standard therapies.
- - Researchers developed two new semisynthetic derivatives of betulinic acid (BA1 and BA2), which exhibited higher antiproliferative effects against A375 human melanoma cells compared to other known compounds, indicating their potential as effective anticancer agents.
- - The study also uncovered antibacterial and antifungal properties of some of these derivatives, which had never been reported before, suggesting their broader application in treating infections alongside cancer.