Publications by authors named "Alexandra DeBose-Scarlett"
Background: Predicted heart mass ratio (PHMr) has become the standard donor-recipient size matching method in heart transplantation. While utilization of small PHMr hearts is associated with increased one-year mortality, the underlying mechanisms and time horizon of mortality remain uncertain.
Methods: A single institution analysis of isolated heart transplant recipients (01/2019-7/2022) was performed (N=334).
Objective: This study was designed to explore key safety outcomes after operating room (OR) extubation in minimally invasive cardiac valve surgery.
Design: Single-center retrospective chart review.
Setting: Academic medical center in the United States.
Article Synopsis
- Recovery methods for hearts from donation after circulatory death include direct procurement and perfusion (DPP) using the TransMedics Organ Care System and normothermic regional perfusion (NRP) followed by cold storage, but it's unclear which offers better post-transplant results.
- A study of heart transplant recipients at Vanderbilt University Medical Center compared outcomes of NRP and DPP, focusing on severe primary graft dysfunction within 24 hours post-surgery.
- Both methods showed similar rates of severe dysfunction at 24 hours, but NRP resulted in a higher ejection fraction after 7 days; more research is needed to further evaluate these recovery strategies.
Background: Blunt cardiac injuries rarely result in aortic valve cusp rupture, leading to acute aortic insufficiency and cardiogenic shock. This rare clinical entity carries a high mortality rate if left undiagnosed and not managed surgically, with few patients surviving beyond 24 h. It presents a diagnostic challenge in the polytrauma patient in shock, with multiple possible and complementary etiologies.
View Article and Find Full Text PDFBackground: Heart transplantation using donation after circulatory death (DCD) allografts is increasingly common, expanding the donor pool and reducing transplant wait times. However, data remain limited on clinical outcomes.
Objectives: We sought to compare 6-month and 1-year clinical outcomes between recipients of DCD hearts, most of them recovered with the use of normothermic regional perfusion (NRP), and recipients of donation after brain death (DBD) hearts.
Background: Hepatitis C virus (HCV) treatment regimens (DAAs) are well tolerated, efficacious but costly. Their high cost and restricted availability, raises concerns about the outcome of treatment in uninsured patients. This study investigated sustained virologic response (SVR) outcomes in a predominately uninsured patient population and completion of four steps along the HCV treatment cascade.
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